Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923835 | 0.82 | TAAR1 (0.43) | SIGMAR1SLC6A2SLC6A4SLC6A3SOS1 | |
| SCHEMBL8409705 | 0.81 | SIGMAR1 (0.47) | SIGMAR1SLC6A2SLC6A4SOS1GBA1 | |
| SCHEMBL1624124 | 0.76 | SMYD3 (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1624127 | 0.76 | SMYD3 (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7457154 | 0.73 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3GBA1 | |
| SCHEMBL27288939 | 0.73 | GBA1 (0.43) | SIGMAR1SLC6A2SLC6A4SLC6A3GBA1 | |
| SCHEMBL8967951 | 0.72 | SIGMAR1 (0.44) | SIGMAR1SLC6A2SLC6A4SLC6A3GBA1 | |
| SCHEMBL3289149 | 0.71 | ATM (0.50) | — | |
| SCHEMBL5780237 | 0.71 | ATM (0.50) | — | |
| SCHEMBL27533342 | 0.71 | ATM (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-B1 | 7-SUBSTITUTED-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS; 7-SUBSTITUTED-1-CYCLOPROPYL-1,4-DIHYDRO-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS; THEIR DERIVATIVES; AND A PROCESS FOR PREPARING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1989-12-27 | — | — | EP | disclosed |