Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26125032 | 0.89 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL27308031 | 0.86 | HPGD (0.45) | SIGMAR1 | |
| SCHEMBL21362848 | 0.84 | HPGD (0.48) | — | |
| SCHEMBL16726956 | 0.82 | USP2 (0.38) | SIGMAR1 | |
| SCHEMBL24324182 | 0.76 | SIGMAR1 (0.40) | SIGMAR1 | |
| SCHEMBL1558858 | 0.73 | SIGMAR1 (0.45) | SLC6A2SIGMAR1 | |
| SCHEMBL8967951 | 0.73 | SIGMAR1 (0.44) | GBA1MC4RSLC6A2SLC6A4JAK3 | |
| SCHEMBL8409705 | 0.73 | SIGMAR1 (0.47) | GBA1HRH1SLC6A2SLC6A4SOS1 | |
| SCHEMBL8781617 | 0.73 | GBA1 (0.51) | GBA1MC4RHRH1SLC6A2SLC6A4 | |
| SCHEMBL27508740 | 0.72 | CYP3A4 (0.43) | MC4RNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0804434-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004274-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-15 | — | — | WO | disclosed |