SCHEMBL8409906

SCHEMBL8409906

COC(=O)c1ccc(COc2ccc(Br)cc2CCc2ccccc2)nc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR6 P51684 1/20 0.44
HKDC1 Q2TB90 1/20 0.44
PTGER1 P34995 4/20 0.43
CCR5 P51681 3/20 0.43
SMPD1 P17405 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
CYP1A2 P05177 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 2/20 0.43
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
USP28 Q96RU2 1/20 0.43
USP25 Q9UHP3 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8324992 0.92 CCR5 (0.48) PTGER1CCR5SMPD1HDAC1HDAC8
SCHEMBL8406036 0.89 PTGER1 (0.47) PTGER1CCR5CYP1A2USP28USP25
SCHEMBL8324940 0.86 CCR5 (0.53) CCR6HKDC1PTGER1CCR5SMPD1
SCHEMBL8409537 0.86 CCR5 (0.53) CCR6HKDC1PTGER1CCR5SMPD1
SCHEMBL8318734 0.80 PTGER1 (0.58) PTGER1CCR5SMPD1HDAC1HDAC8
SCHEMBL8409907 0.80 PTGER1 (0.40) PTGER1CCR5SMPD1HDAC8CYP1A2
SCHEMBL8408175 0.79 HPGD (0.56) PTGER1SMPD1HDAC1HDAC8HDAC6
SCHEMBL7662467 0.79 CCR5 (0.45) PTGER1CCR5SMPD1HDAC1HDAC8
SCHEMBL8325607 0.78 PTGER1 (0.52) PTGER1KMT2ALMNAL3MBTL1RAB9A
SCHEMBL8327306 0.78 GCK (0.53) PTGER1SMPD1HDAC1HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP disclosed
US-5965741-A ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES ZENECA LIMITED (GB) 1999-10-12 US disclosed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed
WO-1996006822-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1996-03-07 WO disclosed