Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675115 | 0.91 | GCK (0.63) | GCKSMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL8405916 | 0.87 | SMN1; SMN2 (0.53) | GCKSMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL8324992 | 0.86 | CCR5 (0.48) | SMN1; SMN2RAB9AHTTHPGDLMNA | |
| SCHEMBL8325607 | 0.85 | PTGER1 (0.52) | RAB9AMAPTHPGDLMNAPTGER1 | |
| SCHEMBL8326786 | 0.83 | PTGER1 (0.42) | SMN1; SMN2RAB9AMAPTNPC1HPGD | |
| SCHEMBL8321962 | 0.83 | PTGER1 (0.56) | GCKSMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL8323253 | 0.79 | PTGER4 (0.59) | RAB9AMAPTHPGDLMNAMTNR1B | |
| SCHEMBL8409245 | 0.79 | PTGER1 (0.58) | GCKSMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL8409906 | 0.78 | CCR6 (0.44) | RAB9AKDM4ELMNASMPD1HDAC1 | |
| SCHEMBL8408175 | 0.77 | HPGD (0.56) | SMN1; SMN2RAB9AMAPTNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |