Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.69 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075588 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL6075567 | 0.84 | MTNR1A (0.70) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL6076480 | 0.84 | MTNR1A (0.70) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL6077100 | 0.84 | MTNR1A (0.70) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL8409987 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL6076023 | 0.79 | MTNR1A (0.64) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL8409084 | 0.78 | MTNR1A (0.62) | MTNR1AMTNR1BHTR1ACA1CA2 | |
| SCHEMBL6076578 | 0.76 | MTNR1A (0.60) | MTNR1AMTNR1BHTR1A | |
| SCHEMBL7516393 | 0.71 | HTR1A (0.49) | MTNR1AMTNR1BHTR1AHTR1DHTR1B | |
| SCHEMBL7201548 | 0.70 | HTR1A (0.48) | MTNR1AMTNR1BHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |