Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | RXRB | P28702 | 6/20 | 0.34 |
| ▸ | RXRG | P48443 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413617 | 0.94 | HDAC1 (0.38) | RXRARXRBRXRGHDAC1HDAC8 | |
| SCHEMBL8413474 | 0.82 | TBXAS1 (0.33) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8412792 | 0.81 | HDAC1 (0.32) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8412823 | 0.78 | HDAC1 (0.32) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL8412765 | 0.78 | RXRA (0.37) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8413364 | 0.78 | PTGIR (0.46) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8411148 | 0.77 | RXRA (0.39) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8413481 | 0.77 | PPARG (0.36) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8414356 | 0.76 | RXRB (0.38) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8411309 | 0.76 | PTGIR (0.43) | TBXAS1CFTRSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | claimed |
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |