Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 9/20 | 0.38 |
| ▸ | RXRB | P28702 | 9/20 | 0.38 |
| ▸ | RXRG | P48443 | 6/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 2/20 | 0.33 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410755 | 0.94 | TBXAS1 (0.35) | HDAC1HDAC8HDAC6RXRARXRB | |
| SCHEMBL8412765 | 0.83 | RXRA (0.37) | RXRARXRBRXRGMCL1PPARG | |
| SCHEMBL8411148 | 0.82 | RXRA (0.39) | RXRARXRBRXRGMCL1PPARG | |
| SCHEMBL8413481 | 0.82 | PPARG (0.36) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8414356 | 0.81 | RXRB (0.38) | RXRARXRBRXRGMCL1PPARG | |
| SCHEMBL8413682 | 0.80 | POLB (0.43) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8414354 | 0.78 | RXRA (0.39) | RXRARXRBRXRGMCL1PPARG | |
| SCHEMBL8410982 | 0.78 | RXRA (0.37) | RXRARXRBRXRGMCL1PPARG | |
| SCHEMBL8413474 | 0.75 | TBXAS1 (0.33) | HDAC1HDAC8HDAC6RXRARXRB | |
| SCHEMBL8414114 | 0.74 | PTGIR (0.38) | RXRARXRBRXRGMCL1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |