Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411297 | 1.00 | ALDH1A1 (0.37) | ALDH1A1ALOX15KDM4EHSD17B10CPB1 | |
| SCHEMBL30988910 | 0.80 | MAPT (0.44) | ALDH1A1SIGMAR1NPC1RAB9AMAPT | |
| SCHEMBL8464052 | 0.80 | MAPT (0.44) | ALDH1A1SIGMAR1NPC1RAB9AMAPT | |
| SCHEMBL7949972 | 0.76 | MAPT (0.44) | ALDH1A1KDM4EHSD17B10MAPTPKM | |
| SCHEMBL30522632 | 0.72 | SIGMAR1 (0.40) | ALDH1A1SIGMAR1NPC1RAB9AMAPT | |
| SCHEMBL8818299 | 0.72 | ALDH1A1 (0.43) | ALDH1A1SIGMAR1NPC1RAB9AMAPT | |
| SCHEMBL7949940 | 0.71 | SMYD3 (0.46) | ALDH1A1ALOX15CPB1MAPTKMT2A | |
| SCHEMBL7952329 | 0.71 | HSD11B1 (0.43) | ALDH1A1ALOX15HSD17B10NPC1RAB9A | |
| SCHEMBL7599608 | 0.67 | MAPT (0.54) | ALDH1A1KDM4EHSD17B10SIGMAR1NPC1 | |
| SCHEMBL31316696 | 0.67 | MAPT (0.54) | ALDH1A1KDM4EHSD17B10SIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930075-A1 | METHODS FOR PREVENTING, INHIBITING OR TREATING GRAFT REJECTION REACTIONS IN GRAFT-VERSUS-HOST DISEASE (GVHD) AND ORGAN TRANSPLANTATION | Eisai Co., Ltd. (JP) | 1999-07-21 | — | — | EP | claimed |