SCHEMBL8411463

SCHEMBL8411463

NC(CS)C(=O)c1ccccc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.48
HPGD P15428 7/20 0.48
ALDH1A1 P00352 4/20 0.48
TSHR P16473 4/20 0.48
HSD17B10 Q99714 4/20 0.48
MAPT P10636 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.45
CA1 P00915 2/20 0.45
CA9 Q16790 2/20 0.45
CA12 O43570 1/20 0.45
CA2 P00918 1/20 0.45
HMGB1 P09429 1/20 0.45
CA4 P22748 1/20 0.45
CA6 P23280 1/20 0.45
CA7 P43166 1/20 0.45
NAPRT Q6XQN6 1/20 0.45
CA14 Q9ULX7 1/20 0.45
TDP1 Q9NUW8 3/20 0.41
HIF1A Q16665 2/20 0.41
GAA P10253 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8411467 1.00 KDM4E (0.48) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL10824784 1.00 KDM4E (0.48) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL11179021 0.83 KDM4E (0.50) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL7613313 0.81 TDP1 (0.49) KDM4EHPGDALDH1A1TSHRHSD17B10
Salicylic Acid SCHEMBL6896514 0.81 ALDH1A1 (0.60) KDM4EHPGDALDH1A1TSHRHSD17B10
Salicylic Acid SCHEMBL6896510 0.81 ALDH1A1 (0.60) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL29524852 0.80 KDM4E (0.52) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL30367223 0.80 KDM4E (0.48) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL5007585 0.80 HPGD (0.47) KDM4EHPGDALDH1A1TSHRHSD17B10
SCHEMBL6896518 0.78 TDP1 (0.50) KDM4EHPGDALDH1A1TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61137817-A None JP disclosed
CN-109431828-B Topical lightening compositions and methods of use thereof 雅芳产品公司 2021-11-12 CN disclosed
CN-108883316-A Skin-lightening, sunscreen, vitamin D-generating compositions 欧内斯特·阿姆斯特朗 2018-11-23 CN disclosed
US-5925332-A RADIOACTIVE LABELS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 1999-07-20 US disclosed
US-5756068-A Methods of radioimaging and radiochemotherapy using phenolic thioeter amines and acyl derivatives thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 1998-05-26 US disclosed
EP-0650473-B1 RADIOIMAGING AND RADIOCHEMOTHERAPY PHENOLIC THIOETHER AMINES AND ACYL DERIVATIVES THEREOF FOR USE IN DIAGNOSING AND TREATING PIGMENTATION DISORDERS UNIV ALBERTA (CA) 1997-05-28 EP disclosed
EP-0650473-A1 RADIOIMAGING AND RADIOCHEMOTHERAPY PHENOLIC THIOETHER AMINES AND ACYL DERIVATIVES THEREOF FOR USE IN DIAGNOSING AND TREATING PIGMENTATION DISORDERS. UNIV ALBERTA (CA) 1995-05-03 EP disclosed
US-5395611-A Cysteaminylphenol derivatives THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 1995-03-07 US disclosed
EP-0526502-B1 PHENOLIC AMINE DEPIGMENTING AND ANTIMELANOMA AGENTS UNIV ALBERTA (CA) 1995-02-22 EP disclosed
WO-1994002456-A1 RADIOIMAGING AND RADIOCHEMOTHERAPY PHENOLIC THIOETHER AMINES AND ACYL DERIVATIVES THEREOF FOR USE IN DIAGNOSING AND TREATING PIGMENTATION DISORDERS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 1994-02-03 WO disclosed
EP-0526502-A1 PHENOLIC AMINE DEPIGMENTING AND ANTIMELANOMA AGENTS. UNIV ALBERTA (CA) 1993-02-10 EP disclosed
WO-1991016302-A1 PHENOLIC AMINE DEPIGMENTING AND ANTIMELANOMA AGENTS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 1991-10-31 WO disclosed
JP-S61137817-A REMEDY FOR HYPERPIGMENTATION DISEASE TORAY IND INC 1986-06-25 JP disclosed