Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516311 | 0.84 | PRKCI (0.52) | PRKCIACHEPDE10ACASP1CA1 | |
| SCHEMBL9742172 | 0.84 | EGFR (0.43) | PRKCIACHEGABRA1GABRB2HTT | |
| SCHEMBL9742175 | 0.84 | EGFR (0.43) | PRKCIACHEGABRA1GABRB2HTT | |
| SCHEMBL14283741 | 0.84 | EGFR (0.43) | PRKCIACHEGABRA1GABRB2HTT | |
| SCHEMBL10907779 | 0.78 | HTT (0.62) | PRKCIACHEPDE10AHTTALDH1A1 | |
| SCHEMBL8442677 | 0.78 | KLF10 (0.61) | TSHRGABRA1GABRB2HTTALDH1A1 | |
| SCHEMBL3819967 | 0.78 | GABRA1 (0.68) | PRKCIACHEPDE10ACA1CA2 | |
| SCHEMBL6029792 | 0.78 | PRKCI (0.53) | PRKCIACHEPDE10ACASP1CA1 | |
| SCHEMBL29939053 | 0.78 | PRKCI (0.53) | PRKCIACHEPDE10ACASP1CA1 | |
| SCHEMBL440146 | 0.77 | PRKCI (0.68) | PRKCIACHEPDE10ACASP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866611-A | PHENOXYPROPYLAMINE INHIBITORS OF SQUALENE SYNTHESE, USEFUL IN TREATING DISEASES IN WHICH A LOWERING OF CHOLESTEROL IS DESIRABLE. | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| EP-0589018-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1994-03-30 | — | — | EP | disclosed |
| WO-1993020807-A1 | AMINES AS INHIBITORS OF SQUALENE SYNTHASE | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |