Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558186 | 0.86 | NOTUM (0.42) | NOTUMALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL8417011 | 0.84 | CYP4F2 (0.52) | NOTUMALDH1A1HSD17B10KDM4ETSHR | |
| SCHEMBL8575697 | 0.82 | NOTUM (0.44) | NOTUMALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL8415367 | 0.80 | SCN9A (0.38) | ALDH1A1KDM4EMAPTCASP1CASP7 | |
| Hydrochloric Acid SCHEMBL8576052 | 0.78 | TDP1 (0.48) | ALDH1A1HSD17B10HPGDTSHRMEN1 | |
| SCHEMBL8414048 | 0.78 | LMNA (0.42) | NOTUMALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL31058340 | 0.76 | MEN1 (0.49) | ALDH1A1KDM4ETSHRMAPTCASP1 | |
| SCHEMBL8572572 | 0.72 | MEN1 (0.38) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL30410323 | 0.70 | TSHR (0.49) | NOTUMALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL14360117 | 0.70 | TSHR (0.49) | NOTUMALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880284-A | HAVING ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASES-INHIBITING EFFECTS | DR. KARL THOMAE GMBH (DE) | 1999-03-09 | — | — | US | disclosed |
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5681841-A | PREVENTION CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |