Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414043 | 0.82 | NOTUM (0.46) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL8575701 | 0.79 | FAAH (0.40) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL2191985 | 0.75 | LMNA (0.58) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL14360117 | 0.71 | TSHR (0.49) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL30410323 | 0.71 | TSHR (0.49) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL27613400 | 0.70 | ALDH1A1 (0.48) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL8414091 | 0.69 | ALDH1A1 (0.39) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL1470873 | 0.69 | FFAR4 (0.46) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL18591613 | 0.68 | LMNA (0.56) | NOTUMALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL8558186 | 0.68 | NOTUM (0.42) | NOTUMALDH1A1HSD17B10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |