Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 7/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.54 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.54 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415885 | 0.84 | GRIA2 (0.59) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8413913 | 0.84 | GRIA2 (0.51) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8413837 | 0.83 | VCAM1 (0.47) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8415935 | 0.83 | GRIA2 (0.50) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL31236083 | 0.76 | GRIA2 (0.65) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8414052 | 0.76 | GRIA2 (0.65) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8415292 | 0.76 | GRIA2 (0.65) | GRIA2GRIA1GRIA3GRIA4GRIK1 | |
| SCHEMBL8542275 | 0.74 | ALDH1A1 (0.56) | MAPTCYP3A4HPGDTSHRVCAM1 | |
| SCHEMBL13717956 | 0.74 | VCAM1 (0.55) | CYP1A2MAPTLMNACYP3A4HPGD | |
| Dnqx SCHEMBL594575 | 0.73 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912245-A | AMPA AND KAINATE ANTAGONISTS. | EGIS GYOGYSZERGYAR RT. (HU) | 1999-06-15 | — | — | US | disclosed |
| EP-0759910-A1 | ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | EGIS GYOGYSZERGYAR RT. (HU) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995031443-A1 | ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | EGIS Gyógyszergyár Rt. (HU) | 1995-11-23 | — | — | WO | disclosed |