Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 14/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812817 | 0.90 | PTGIR (0.46) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8414321 | 0.89 | MTNR1A (0.45) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8414288 | 0.87 | MTNR1A (0.48) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8811674 | 0.84 | PTGIR (0.46) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL9017300 | 0.82 | DRD2 (0.63) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL7777377 | 0.81 | CYP19A1 (0.64) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8808898 | 0.80 | PTGIR (0.54) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8808903 | 0.80 | PTGIR (0.54) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL9048569 | 0.79 | PTGIR (0.47) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL8414260 | 0.78 | PTGIR (0.65) | PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0548949-B1 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5589496-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor agonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-12-31 | — | — | US | disclosed |
| US-5389666-A | Administering for treatment and prevention of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer or hypertension | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0548949-A2 | Fused benzeneoxyacetic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |