Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443611 | 0.82 | MGAM (0.61) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL8617775 | 0.81 | MGAM (0.49) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL28549098 | 0.77 | RAB9A (0.45) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL28549101 | 0.77 | RAB9A (0.45) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL28605670 | 0.75 | CNR2 (0.62) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL9493916 | 0.73 | CES2 (0.56) | ALDH1A1KMT2ACYP1A2HPGDLMNA | |
| SCHEMBL12256867 | 0.72 | MGAM (0.64) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL22501398 | 0.71 | KDM4E (0.66) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL22501419 | 0.71 | RAB9A (0.50) | RAB9ANPC1MGAMCNR2SMN1; SMN2 | |
| SCHEMBL7978993 | 0.71 | HDAC8 (0.42) | RAB9ANPC1MGAMCNR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937044-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998005642-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-02-12 | — | — | WO | disclosed |