Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408599 | 0.80 | CES2 (0.58) | GRM4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL8973454 | 0.79 | CES2 (0.45) | GRM4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL28801333 | 0.78 | CTNNB1 (0.57) | GRM4NPC1RAB9APKMKMT2A | |
| SCHEMBL8416284 | 0.78 | ALDH1A1 (0.51) | GRM4SMN1; SMN2MITFKMT2AMEN1 | |
| SCHEMBL28472398 | 0.78 | CTNNB1 (0.57) | GRM4NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL17842156 | 0.78 | GRM4 (0.64) | GRM4NPC1RAB9ASMN1; SMN2MITF | |
| Methyl Alcohol SCHEMBL28478481 | 0.78 | ALDH1A1 (0.58) | GRM4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL9493916 | 0.77 | CES2 (0.56) | KMT2ACES2CES1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL23294769 | 0.75 | L3MBTL1 (0.58) | GRM4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL17842486 | 0.75 | RAB9A (0.55) | GRM4NPC1RAB9ASMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937044-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998005642-A1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-02-12 | — | — | WO | disclosed |