SCHEMBL8415348

SCHEMBL8415348

Cc1cn([C@@]2(CC(N)C(=O)CCCCCN)C[C@H](O)[C@@H](CO)O2)c(=O)nc1N

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 4/20 0.32
DNMT3B Q9UBC3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776347 0.85 PDE3A (0.36)
SCHEMBL8415346 0.84
SCHEMBL2580879 0.68 PDE3A (0.41) DNMT1
SCHEMBL8028514 0.67
SCHEMBL5500343 0.67 DNMT1 (0.33) DNMT1
SCHEMBL8581452 0.65 DNMT1 (0.31) DNMT1
SCHEMBL7638345 0.65 DNMT1 (0.40) DNMT1DNMT3B
SCHEMBL8583926 0.65 DNMT1 (0.30) DNMT1DNMT3B
SCHEMBL1684840 0.65 DNMT1 (0.34) DNMT1
SCHEMBL10345052 0.64 DNMT1 (0.31) DNMT1DNMT3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0510085-B1 DNA-DEPENDENT RNA POLYMERASE TRANSCRIPTS AS REPORTER MOLECULES FOR SIGNAL AMPLIFICATION IN NUCLEIC ACID HYBRIDIZATION ASSAYS CHIRON DIAGNOSTICS CORP (US) 1999-09-08 EP disclosed
US-5629153-A DIAGNOSIS CHIRON CORPORATION (US) 1997-05-13 US disclosed