SCHEMBL8415404

SCHEMBL8415404

CS(=O)(=O)Nc1ccc(S(=O)(=O)Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.64
CA1 P00915 1/20 0.64
CA2 P00918 1/20 0.64
CA9 Q16790 1/20 0.64
CYP2C9 P11712 1/20 0.61
KIF11 P52732 3/20 0.57
ALDH1A1 P00352 4/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
MAPT P10636 1/20 0.56
KEAP1 Q14145 1/20 0.56
LMNA P02545 3/20 0.55
KDM4E B2RXH2 1/20 0.55
HPGD P15428 1/20 0.55
HTT P42858 1/20 0.55
MAPK1 P28482 3/20 0.53
GAA P10253 1/20 0.53
NPSR1 Q6W5P4 1/20 0.50
PGR P06401 1/20 0.48
NR3C2 P08235 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12054668 0.83 KEAP1 (0.75) CA12CA1CA2CA9CYP2C9
SCHEMBL28014642 0.82 CA12 (0.69) CA12CA1CA2CA9CYP2C9
SCHEMBL7018062 0.79 HPGD (0.60) CA12CA1CA2CA9CYP2C9
SCHEMBL6401779 0.78 CA12 (0.64) CA12CA1CA2CA9CYP2C9
SCHEMBL6401783 0.78 CA2 (1.00) CA12CA1CA2CA9CYP2C9
SCHEMBL6839436 0.78 CA12 (0.64) CA12CA1CA2CA9CYP2C9
SCHEMBL479173 0.77 KIF11 (0.88) CA12CA1CA2CA9CYP2C9
SCHEMBL5575093 0.77 CA12 (0.61) CA12CA1CA2CA9CYP2C9
SCHEMBL31041151 0.77 KIF11 (0.79) CA12CA1CA2CA9CYP2C9
SCHEMBL6400945 0.76 KEAP1 (0.53) CA12CA1CA2CA9KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791004-B1 ACYLATED BENZYLGLYCOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PROD (US) 1999-09-08 EP disclosed
US-5773420-A Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-30 US disclosed
EP-0791004-A1 ACYLATED BENZYLGLYCOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-27 EP disclosed
WO-1996014325-A1 ACYLATED BENZYLGLYCOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO disclosed
EP-0700385-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-03-13 EP disclosed
WO-1995007884-A1 ALKANEDIAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIC AND ISCHAEMIC RHYTHM DISORDERS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1995-03-23 WO disclosed
WO-1994027967-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1994-12-08 WO disclosed
US-5223623-A 2-substituted-1(4)-aryl piperazines and the process for their preparation SCHERING AG (DE) 1993-06-29 US disclosed
US-5149700-A Antiarrhythmic agent AMERICAN HOME PRODUCTS CORPORATION (US) 1992-09-22 US disclosed
US-5144072-A Anti-arrhythmic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-09-01 US disclosed
EP-0491709-A1 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION SCHERING AKTIENGESELLSCHAFT (DE) 1992-07-01 EP disclosed
WO-1991018904-A1 SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES AMERICAN HOME PRODUCTS CORPORATION (US) 1991-12-12 WO disclosed
US-5051422-A 2-substituted-1(4)-aryl piperazines and the process for their preparation SCHERING AG (DE) 1991-09-24 US disclosed
WO-1991004250-A1 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) 1991-04-04 WO disclosed
EP-0260901-B1 BENZENESULPHONAMIDES USEFUL AS ANTI-ARRYTHMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1991-03-06 EP disclosed
US-4935515-A ANTIARRHYTHMIA AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1990-06-19 US disclosed
US-4882323-A ANTIARRYTHMIA AGENT INTERMEDIATES AMERICAN HOME PRODUCTS (US) 1989-11-21 US disclosed
EP-0260901-A1 Benzenesulphonamides useful as anti-arrythmic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1988-03-23 EP disclosed
US-4721809-A Alkylsulfonamido or perfluoroalkylsulfonamido benzenesulfonamides AMERICAN HOME PRODUCTS CORPORATION (US) 1988-01-26 US disclosed