Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412134 | 0.90 | ALDH1A1 (0.41) | HPGDALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL8411821 | 0.83 | ALDH1A1 (0.31) | HPGDALDH1A1 | |
| SCHEMBL7894235 | 0.76 | L3MBTL1 (0.36) | TSHRHPGDPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7894151 | 0.74 | MAPT (0.40) | TSHRHPGDPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7895615 | 0.74 | L3MBTL1 (0.39) | TSHRHPGDPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7896944 | 0.71 | L3MBTL1 (0.34) | TSHRHPGDPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7894266 | 0.70 | PLK1 (0.40) | TSHRHPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7895193 | 0.68 | L3MBTL1 (0.32) | TSHRHPGDALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4261100 | 0.66 | ALDH1A1 (0.42) | HPGDALDH1A1SMN1; SMN2P2RX7 | |
| SCHEMBL7887027 | 0.65 | PLK1 (0.35) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934257-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998002413-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-22 | — | — | WO | claimed |
| EP-0934257-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998002413-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |