SCHEMBL7895615

SCHEMBL7895615

Cc1cc(C)c(CNc2c(NC(C)(C)C)c(=O)c2=O)c(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.39
HTT P42858 1/20 0.38
TSHR P16473 1/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 1/20 0.33
LMNA P02545 1/20 0.31
RAPGEF4 Q8WZA2 4/20 0.31
EPHX2 P34913 1/20 0.31
DHFR P00374 1/20 0.31
ROCK2 O75116 2/20 0.30
CHEK2 O96017 2/20 0.30
PRKACA P17612 2/20 0.30
RPS6KB1 P23443 2/20 0.30
AKT1 P31749 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7894120 0.90 CHEK2 (0.33) L3MBTL1HTTRAPGEF4ROCK2CHEK2
SCHEMBL7599531 0.89 ALDH1A1 (0.44) ALDH1A1HPGDSMN1; SMN2RAPGEF4EPHX2
SCHEMBL7894235 0.88 L3MBTL1 (0.36) L3MBTL1HTTTSHRALDH1A1HPGD
SCHEMBL7894266 0.82 PLK1 (0.40) L3MBTL1HTTTSHRALDH1A1HPGD
SCHEMBL7895193 0.81 L3MBTL1 (0.32) L3MBTL1HTTTSHRALDH1A1HPGD
SCHEMBL7895628 0.81 ROCK2 (0.32) ALDH1A1ROCK2CHEK2PRKACARPS6KB1
SCHEMBL7895056 0.81 CYP3A4 (0.41) HPGDHDAC8
SCHEMBL7896944 0.80 L3MBTL1 (0.34) L3MBTL1HTTTSHRALDH1A1HPGD
Tetrahydrofuran SCHEMBL8519861 0.80 PLK1 (0.33) MAPT
SCHEMBL7894237 0.78 HPGD (0.39) L3MBTL1HTTALDH1A1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP claimed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP claimed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US claimed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO claimed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed