Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perastine SCHEMBL1506306 | 0.83 | CYP3A4 (0.83) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| Perastine SCHEMBL29768269 | 0.82 | CYP3A4 (0.83) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| SCHEMBL5708552 | 0.82 | TSHR (0.67) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| SCHEMBL7332031 | 0.80 | SLC6A4 (0.57) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| SCHEMBL11398777 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| Cloperastine SCHEMBL284715 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| SCHEMBL17942915 | 0.76 | CYP3A4 (0.75) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| Cloperastine SCHEMBL9613613 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| Cloperastine SCHEMBL29617329 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A3CYP3A4DRD1CYP1A2 | |
| SCHEMBL14033921 | 0.76 | LTA4H (0.97) | DRD1LTA4HDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856341-A | INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, CARDIOVASCULAR-RELATED PATHOLOGICAL CONDITIONS INCLUDING HYPERLIPIDEMIA, ESTROGEN-DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-01-05 | — | — | US | disclosed |