Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | ULK1 | O75385 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.56 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.56 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.56 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.56 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 7/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.48 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276026 | 0.80 | MMP12 (0.56) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL8295987 | 0.80 | PARP1 (0.44) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL563860 | 0.80 | CDK5 (0.40) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL2000402 | 0.74 | CDK5 (1.00) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL1987425 | 0.72 | CDK5 (1.00) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL4792557 | 0.71 | CHEK1 (0.42) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL14629877 | 0.71 | JAK2 (0.59) | TYK2GAA | |
| SCHEMBL1988192 | 0.71 | CDK5 (1.00) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL1990461 | 0.71 | CDK5 (0.66) | CDK5CDK5R1DYRK1AULK1CDK7 | |
| SCHEMBL14629898 | 0.71 | JAK2 (0.50) | MMP12TYK2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007765-B1 | IMMUNOPOTENTIATING COMPOUNDS | NOVARTIS AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| US-8143270-B2 | 2-amino 1H-in-imidazo ring systems and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8063063-B2 | Immunopotentiating compounds | NOVARTIS AG (CH) | 2011-11-22 | — | — | US | disclosed |
| US-20090232844-A1 | IMMUNOPOTENTIATING COMPOUNDS | NOVARTIS AG (CH) | 2009-09-17 | — | — | US | disclosed |
| EP-1784180-A4 | 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2009-07-22 | — | — | EP | disclosed |
| US-20090023720-A1 | 2-Amino 1H-Imidazo Ring Systems and Methods | 3M INNOVATIVE PROPERTIES COMPANY | 2009-01-22 | — | — | US | disclosed |
| EP-2007765-A2 | IMMUNOPOTENTIATING COMPOUNDS | Novartis AG (CH) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007109812-A2 | IMMUNOPOTENTIATING COMPOUNDS | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
| EP-1784180-A2 | 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006029115-A2 | 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023720-A1 | 2-Amino 1H-Imidazo Ring Systems and Methods | IL2, IL2RA, IL4I1 | CDK5 668/4885CDK5R1 403/4885DYRK1A 3791/4885 |
| US-20090232844-A1 | IMMUNOPOTENTIATING COMPOUNDS | IFNG, LY96, NFATC1 | CDK5 3441/4885CDK5R1 2993/4885DYRK1A 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.