Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 11/20 | 0.62 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8418202 | 1.00 | KCNH2 (0.62) | KCNH2METTL3METTL14PLA2G4A | |
| Fumaric Acid SCHEMBL8418386 | 0.86 | KCNH2 (0.64) | KCNH2METTL3METTL14 | |
| Maleic Acid SCHEMBL8418382 | 0.86 | KCNH2 (0.64) | KCNH2METTL3METTL14 | |
| Fumaric Acid SCHEMBL8415271 | 0.84 | KCNH2 (0.62) | KCNH2 | |
| Fumaric Acid SCHEMBL8415266 | 0.84 | KCNH2 (0.62) | KCNH2 | |
| Maleic Acid SCHEMBL8416443 | 0.83 | KCNH2 (0.81) | KCNH2 | |
| Fumaric Acid SCHEMBL8416444 | 0.83 | KCNH2 (0.81) | KCNH2 | |
| SCHEMBL8416477 | 0.81 | KCNH2 (0.65) | KCNH2METTL3METTL14 | |
| SCHEMBL8119266 | 0.80 | KCNH2 (0.70) | KCNH2METTL3METTL14PLA2G4A | |
| Fumaric Acid SCHEMBL8417026 | 0.78 | KCNH2 (0.53) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939077-A2 | 3-Substituted 1-arylindole compounds as 5-HT2 antagonists | H. LUNDBECK A/S (DK) | 1999-09-01 | — | — | EP | disclosed |
| US-5789404-A | CENTRAL NERVOUS SYSTEM DISORDERS AND ANTISEROTONIN AGENTS | H. LUNDBECK A/S (DK) | 1998-08-04 | — | — | US | disclosed |