Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | GRB2 | P62993 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446113 | 0.83 | GABRA1 (0.50) | ALDH1A1HPGDNPSR1AKR1B1GABRA1 | |
| SCHEMBL6391049 | 0.81 | PTGDR (0.60) | ALDH1A1LMNACYP2C9TSHRNPSR1 | |
| SCHEMBL28532363 | 0.81 | PTGDR (0.42) | ALDH1A1LMNAHPGDAKR1B1GABRA1 | |
| SCHEMBL1908071 | 0.79 | ALDH1A1 (0.52) | EGFRALDH1A1HPGDTSHRLCK | |
| SCHEMBL6390178 | 0.78 | AKR1B1 (0.55) | AKR1B1GABRA1GABRB2 | |
| SCHEMBL6391086 | 0.78 | HSD17B10 (0.60) | ALDH1A1LMNATSHRLCKMEN1 | |
| SCHEMBL23174983 | 0.77 | GABRA1 (0.44) | TSHRGABRA1GABRB2MEN1POLB | |
| SCHEMBL11486533 | 0.77 | CAMK2A (0.50) | CAMK2AEGFRALDH1A1LMNAGLA | |
| SCHEMBL927675 | 0.77 | CAMK2A (0.50) | CAMK2AEGFRALDH1A1LMNAGLA | |
| Lithium SCHEMBL29605661 | 0.77 | AKR1B1 (0.53) | AKR1B1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |