Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2150158 | 0.90 | CA12 (0.50) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL17226148 | 0.89 | CA12 (0.49) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL9259951 | 0.84 | THRB (0.51) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL8421877 | 0.84 | CA12 (0.45) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL8420396 | 0.84 | LTA4H (0.56) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL1652185 | 0.82 | CA12 (0.50) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL23642842 | 0.82 | LTA4H (0.50) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL19755176 | 0.81 | ALDH1A1 (0.44) | ALDH1A1POLBMAPTUSP2CACNA1B | |
| SCHEMBL28578566 | 0.81 | THRB (0.56) | ALDH1A1MAPTUSP2SMN1; SMN2MEN1 | |
| SCHEMBL8419698 | 0.81 | ALDH1A1 (0.43) | ALDH1A1POLBMAPTUSP2CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |