Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.76 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1556900 | 0.93 | OPRD1 (0.82) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL15734537 | 0.93 | OPRD1 (0.82) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL8769574 | 0.93 | OPRM1 (0.75) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL8769499 | 0.93 | OPRM1 (0.75) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL8770145 | 0.93 | OPRM1 (0.75) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL8770164 | 0.92 | OPRM1 (0.73) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Nicocodine SCHEMBL29531263 | 0.91 | OPRM1 (0.69) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Nicocodine SCHEMBL159020 | 0.91 | OPRM1 (0.69) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Nicocodine SCHEMBL1023092 | 0.91 | OPRM1 (0.69) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| SCHEMBL13250907 | 0.90 | OPRM1 (0.84) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977395-A | ALKYLATION | RHONE-POULENC CHIMIE (FR) | 1999-11-02 | — | — | US | disclosed |
| EP-0793664-A1 | MORPHINE AND CODEINE DERIVATIVES FOR USE IN THERAPY | BTG INTERNATIONAL LIMITED (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5637722-A | ALKYLATION OF NUCLEOPHILE WITH ALKYL PROPARGYL XANTHATE | RHONE-POULENC CHIMIE (FR) | 1997-06-10 | — | — | US | disclosed |
| WO-1996016063-A1 | MORPHINE AND CODEINE DERIVATIVES FOR USE IN THERAPY | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1996-05-30 | — | — | WO | disclosed |