Nicocodine

Nicocodine

SCHEMBL29531263

COc1ccc2c3c1O[C@H]1[C@@H](OC(=O)c4cccnc4)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 12/20 0.69
OPRK1 P41145 9/20 0.69
OPRD1 P41143 4/20 0.69
MRGPRX2 Q96LB1 3/20 0.62
ADRB1 P08588 1/20 0.62
PDE4D Q08499 1/20 0.62
PDE3A Q14432 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nicocodine SCHEMBL1023092 1.00 OPRM1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicocodine SCHEMBL159020 1.00 OPRM1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL26237 0.94 OPRD1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL680036 0.94 OPRD1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL29408441 0.94 OPRD1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL29349768 0.94 OPRD1 (0.69) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL1649977 0.93 OPRD1 (0.68) OPRM1OPRK1OPRD1MRGPRX2ADRB1
Nicomorphine SCHEMBL395672 0.93 OPRD1 (0.68) OPRM1OPRK1OPRD1MRGPRX2ADRB1
SCHEMBL8418756 0.91 OPRM1 (0.76) OPRM1OPRK1OPRD1MRGPRX2ADRB1
SCHEMBL8769499 0.87 OPRM1 (0.75) OPRM1OPRK1OPRD1MRGPRX2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11827651-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-11-28 US claimed
US-12570707-B2 Codon-optimised complement factor I NOVARTIS PHARMACEUTICALS UK LIMITED (GB) 2026-03-10 US disclosed
CN-119876200-A Codon optimized complement factor I 陀螺仪治疗有限公司 2025-04-25 CN disclosed
CN-113383011-B Codon optimized complement factor I 陀螺仪治疗有限公司 2025-02-07 CN disclosed
EP-4386085-A2 CODON-OPTIMISED COMPLEMENT FACTOR I Gyroscope Therapeutics Limited (GB) 2024-06-19 EP disclosed
US-11827651-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-11-28 US disclosed
EP-3588634-B1 IMPROVED ORGANIC ELECTRODE MATERIAL INNOVATIONLAB GMBH (DE) 2023-11-22 EP disclosed
EP-4229076-A1 NUCLEIC ACID ENCODING AN ANTI-VEGF ENTITY AND A NEGATIVE COMPLEMENT REGULATOR AND USES THEREOF FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Gyroscope Therapeutics Limited (GB) 2023-08-23 EP disclosed
US-20230212275-A1 NUCLEIC ACID ENCODING AN ANTI-VEGF ENTITY AND A NEGATIVE COMPLEMENT REGULATOR AND USES THEREOF FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Gyroscope Therapeutics Limited (GB) 2023-07-06 US disclosed
CN-115927412-A Codon optimized complement factor I 陀螺仪治疗有限公司 2023-04-07 CN disclosed
WO-2022079453-A1 NUCLEIC ACID ENCODING AN ANTI-VEGF ENTITY AND A NEGATIVE COMPLEMENT REGULATOR AND USES THEREOF FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Gyroscope Therapeutics Limited (GB) 2022-04-21 WO disclosed
US-20220073576-A1 CODON-OPTIMISED COMPLEMENT FACTOR I Gyroscope Therapeutics Limited (GB) 2022-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570707-B2 Codon-optimised complement factor I CFH, CFB, CFD OPRM1 2792/4885OPRK1 2974/4885OPRD1 2144/4885
US-11827651-B2 Organic electroluminescent materials and devices SSB, L1CAM, LEF1 OPRM1 777/4885OPRK1 1266/4885OPRD1 3145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.