Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8419161 | 0.94 | ALOX15 (0.39) | ALOX15TP53LMNAPOLBMAPT | |
| SCHEMBL8421085 | 0.91 | ALOX15 (0.40) | ALDH1A1ALOX15TP53LMNAPOLB | |
| SCHEMBL8421733 | 0.91 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL8419183 | 0.86 | ALOX15 (0.41) | ALDH1A1ALOX15TP53LMNAPOLB | |
| SCHEMBL8417957 | 0.86 | ALOX15 (0.41) | ALDH1A1ALOX15TP53LMNAPOLB | |
| SCHEMBL8419605 | 0.86 | ALOX15 (0.39) | ALDH1A1ALOX15TP53LMNAPOLB | |
| SCHEMBL8418031 | 0.85 | ABCB11 (0.34) | — | |
| SCHEMBL8422201 | 0.85 | ALOX15 (0.40) | ALDH1A1ALOX15MEN1KMT2ATP53 | |
| SCHEMBL8419566 | 0.81 | ALOX15 (0.37) | ALDH1A1ALOX15TP53LMNAMAPT | |
| SCHEMBL8417426 | 0.81 | TSHR (0.37) | ALOX15MEN1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |