Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417957 | 0.90 | ALOX15 (0.41) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8421085 | 0.89 | ALOX15 (0.40) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8419605 | 0.88 | ALOX15 (0.39) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8419161 | 0.88 | ALOX15 (0.39) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8419174 | 0.86 | ALDH1A1 (0.38) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8422201 | 0.86 | ALOX15 (0.40) | ALOX15TP53MAPTLMNAPOLB | |
| SCHEMBL8421062 | 0.86 | GABRG2 (0.35) | MAPTNPC1MAPK1RAB9APOLB | |
| SCHEMBL8417426 | 0.84 | TSHR (0.37) | ALOX15POLBAGTR2 | |
| SCHEMBL8417855 | 0.84 | ALOX15 (0.36) | ALOX15TP53MAPTLMNAAGTR2 | |
| SCHEMBL8419277 | 0.84 | ALOX15 (0.36) | ALOX15AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |