Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776730 | 0.93 | KDM4E (0.41) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8420941 | 0.92 | MEN1 (0.52) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8419767 | 0.91 | ALDH1A1 (0.42) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8419987 | 0.91 | MCL1 (0.42) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8894050 | 0.88 | MEN1 (0.48) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8423218 | 0.88 | HTT (0.50) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8423281 | 0.86 | KDM4E (0.48) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8421303 | 0.85 | HTT (0.48) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8419770 | 0.85 | KMT2A (0.41) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8421210 | 0.85 | HPGD (0.42) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |