Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ACLY | P53396 | 6/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421023 | 0.88 | LMNA (0.48) | ABCB1ABCC1KITLMNAACLY | |
| SCHEMBL8421215 | 0.87 | ACLY (0.49) | LMNAACLYSMN1; SMN2HPGDKDM4E | |
| SCHEMBL8421017 | 0.87 | TSHR (0.46) | ABCB1ABCC1KITLMNASTAT3 | |
| SCHEMBL8421287 | 0.80 | ACLY (0.50) | ABCB1ABCC1LMNAACLYSTAT3 | |
| SCHEMBL8659801 | 0.79 | STAT3 (0.69) | LMNAACLYSTAT3HPGDL3MBTL1 | |
| SCHEMBL8659675 | 0.78 | STAT3 (0.58) | ABCB1ABCC1LMNAACLYSTAT3 | |
| SCHEMBL8421183 | 0.76 | LMNA (0.48) | LMNAACLYSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6169842 | 0.76 | PTGS2 (0.47) | KITALDH1A1TSHRPTGS1PTGS2 | |
| SCHEMBL8478641 | 0.76 | PTGS2 (0.44) | ABCB1ABCC1KITACLYSTAT3 | |
| SCHEMBL8478256 | 0.74 | PTGS2 (0.42) | ABCB1ABCC1KITAAK1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |