Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421859 | 0.99 | PPARA (0.41) | PPARAPDE3BPDE3AP2RY12ALOX5 | |
| SCHEMBL8419852 | 0.97 | PPARA (0.40) | PPARAALOX5ALDH1A1PPARDKDM4E | |
| SCHEMBL9432238 | 0.89 | PPARA (0.47) | PPARAALOX5PPARDMAPTPPARG | |
| SCHEMBL8969517 | 0.87 | CYP4Z1 (0.40) | PPARAALOX5ALDH1A1LMNA | |
| SCHEMBL8969386 | 0.86 | PPARA (0.46) | PPARAALOX5PPARDPPARG | |
| SCHEMBL8419836 | 0.84 | ALOX5 (0.41) | PPARAALOX5ALDH1A1PPARDKDM4E | |
| SCHEMBL8417976 | 0.84 | PPARA (0.42) | PPARAALOX5PPARD | |
| SCHEMBL8419729 | 0.83 | PPARA (0.39) | PPARAALOX5ALDH1A1PPARDKDM4E | |
| SCHEMBL8418566 | 0.82 | FDFT1 (0.45) | PPARAPDE3BPDE3AP2RY12ALOX5 | |
| SCHEMBL8417735 | 0.82 | PTGDR (0.39) | PPARAALOX5ALDH1A1PPARDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| CN-1121718-A | Heterocyclic derivatives | ZENECA LTD (GB) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |