Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418885 | 0.90 | LTB4R (0.65) | LTB4RLTB4R2APPPKMKDM4E | |
| SCHEMBL4961192 | 0.86 | LTB4R (0.49) | LTB4RLTB4R2APPPTGER1PKM | |
| SCHEMBL8418898 | 0.85 | LTB4R (0.65) | LTB4RLTB4R2APPPTGER1LMNA | |
| SCHEMBL8418922 | 0.84 | LTB4R (0.57) | LTB4RLTB4R2PTGER1ALDH1A1MEN1 | |
| SCHEMBL8420123 | 0.82 | AKR1C3 (0.46) | LTB4RLTB4R2APPLMNA | |
| SCHEMBL8422218 | 0.81 | LTB4R (0.50) | LTB4RLTB4R2APPPTGER1PKM | |
| SCHEMBL8418430 | 0.81 | LTB4R (0.52) | LTB4RLTB4R2APPPKMLMNA | |
| SCHEMBL7976804 | 0.79 | LTB4R (0.82) | LTB4RLTB4R2 | |
| SCHEMBL7976808 | 0.79 | LTB4R (0.82) | LTB4RLTB4R2 | |
| SCHEMBL7976799 | 0.79 | LTB4R (0.82) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |