Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 known ✓ | Q99500 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL15570844 | 0.90 | TSHR (0.56) | TSHRRECQLHPGDMAPK1GLA | |
| Salicylic Acid SCHEMBL8420136 | 0.86 | NAAA (0.50) | TSHRHPGDMAPK1ALDH1A1LMNA | |
| Phenol SCHEMBL27566168 | 0.84 | TSHR (0.67) | TSHRRECQLHPGDMAPK1GLA | |
| Phenol SCHEMBL27985589 | 0.84 | TSHR (0.67) | TSHRRECQLHPGDMAPK1GLA | |
| Salicylic Acid SCHEMBL27785968 | 0.82 | ALDH1A1 (0.56) | TSHRRECQLHPGDMAPK1ALDH1A1 | |
| Hexadecane SCHEMBL28225619 | 0.82 | ALDH1A1 (0.69) | TSHRHPGDALDH1A1LMNACA12 | |
| Dodecane SCHEMBL6692297 | 0.82 | ALDH1A1 (0.69) | TSHRHPGDALDH1A1LMNACA12 | |
| Salicylic Acid SCHEMBL28366261 | 0.82 | ALDH1A1 (0.69) | TSHRHPGDALDH1A1LMNACA12 | |
| Phenol SCHEMBL25246784 | 0.81 | TSHR (0.62) | TSHRRECQLHPGDMAPK1GLA | |
| Dibutyl Phthalate SCHEMBL28221240 | 0.81 | ALDH1A1 (0.71) | TSHRRECQLHPGDMAPK1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5980921-A | A WATER-IN-OIL EMULSION COMPRISING CYCLOMETHICONE, DIMETHICONE, NIACINAMIDE, PANTOTHENIC ACID, GLYCERIN, POLYDIMETHYLSILOXANE, A PIGMENT AND WATER; PROTECTIVE COLLOIDS | THE PROCTER & GAMBLE COMPANY (US) | 1999-11-09 | — | — | US | disclosed |