Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574722 | 0.77 | HSD11B1 (0.36) | HSD11B1LMNAAKR1C1HTTHDAC9 | |
| SCHEMBL27660328 | 0.76 | HSD11B1 (0.35) | HSD11B1LMNAAKR1C1HTTHDAC9 | |
| Hydrochloric Acid SCHEMBL28568646 | 0.76 | HSD11B1 (0.35) | HSD11B1LMNAAKR1C1HTTHDAC9 | |
| SCHEMBL9142790 | 0.76 | HSD11B1 (0.35) | HSD11B1LMNAAKR1C1HTTHDAC9 | |
| SCHEMBL20211715 | 0.73 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL6883947 | 0.72 | LMNA (0.41) | HSD11B1LMNAF2 | |
| SCHEMBL9245983 | 0.70 | LMNA (0.34) | HSD11B1LMNAAKR1C1HTTHDAC9 | |
| SCHEMBL28485724 | 0.70 | HSD11B1 (0.34) | HSD11B1LMNA | |
| SCHEMBL11520353 | 0.70 | GAA (0.36) | HSD11B1HTT | |
| SCHEMBL27648134 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |