Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 4/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421284 | 0.87 | CCR2 (0.34) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL8420167 | 0.82 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL8386573 | 0.79 | HRH3 (0.39) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL4261010 | 0.78 | ABCC9 (0.40) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8624266 | 0.69 | AR (0.33) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL20559738 | 0.69 | CYP2A6 (0.46) | PGRHRH3NOS3NOS1NOS2 | |
| SCHEMBL8895911 | 0.69 | CYP2A6 (0.46) | PGRHRH3NOS3NOS1NOS2 | |
| SCHEMBL8665101 | 0.69 | ABCC9 (0.37) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8381744 | 0.68 | HRH3 (0.40) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL8622441 | 0.68 | PDK1 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872139-A | MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-16 | — | — | US | claimed |
| US-5872139-A | MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-16 | — | — | US | disclosed |