Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 4/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622441 | 0.82 | PDK1 (0.38) | ABCC9KCNJ11ABCC8KCNJ8SCN9A | |
| SCHEMBL8667527 | 0.77 | ABCC9 (0.51) | ABCC9KCNJ11ABCC8KCNJ8GRIA1 | |
| SCHEMBL8668084 | 0.75 | GRIA1 (0.39) | ABCC9KCNJ11ABCC8KCNJ8GRIA1 | |
| SCHEMBL7894240 | 0.75 | LOXL2 (0.45) | ABCC9KCNJ11ABCC8KCNJ8SCN9A | |
| SCHEMBL8664139 | 0.74 | ABCC9 (0.37) | ABCC9KCNJ11ABCC8KCNJ8GRIA1 | |
| SCHEMBL8666923 | 0.72 | CYP19A1 (0.32) | ABCC9KCNJ11ABCC8KCNJ8GRIA1 | |
| SCHEMBL8624266 | 0.71 | AR (0.33) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL4261010 | 0.71 | ABCC9 (0.40) | ABCC9KCNJ11ABCC8KCNJ8HSD11B1 | |
| SCHEMBL8420712 | 0.69 | ABCC9 (0.39) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7898359 | 0.68 | P2RX7 (0.44) | ABCC9KCNJ11ABCC8KCNJ8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | claimed |
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |