Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RGS12 | O14924 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388117 | 0.85 | GAA (0.59) | GAAPOLBMAPTHPGDTDP1 | |
| SCHEMBL8418481 | 0.84 | GABRA1 (0.53) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL18694877 | 0.83 | ALDH1A1 (0.53) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL821126 | 0.82 | GABRA1 (0.72) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL10825727 | 0.82 | GAA (0.70) | GAAPOLBMAPTHPGDTDP1 | |
| SCHEMBL7041553 | 0.81 | ALDH1A1 (0.57) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL6180947 | 0.81 | GABRA1 (0.61) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL16245950 | 0.81 | GABRA1 (0.61) | GAAPOLBMAPTHPGDKDM4E | |
| SCHEMBL11278615 | 0.81 | PTGDR (0.42) | GAAPOLBMAPTHPGDTDP1 | |
| SCHEMBL10388295 | 0.81 | GAA (0.54) | GAAPOLBMAPTHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| US-4918092-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1990-04-17 | — | — | US | disclosed |