Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 12/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418885 | 0.87 | LTB4R (0.65) | LTB4RLTB4R2PKMKDM4EFFAR1 | |
| SCHEMBL8420359 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2FFAR1PPARDPPARG | |
| SCHEMBL8418922 | 0.81 | LTB4R (0.57) | LTB4RLTB4R2PPARDPTGER1MAPT | |
| SCHEMBL7990479 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL7990475 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL7990481 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL8565773 | 0.77 | LTB4R (0.53) | LTB4RLTB4R2PKMKDM4EPTGER1 | |
| SCHEMBL8418898 | 0.77 | LTB4R (0.65) | LTB4RLTB4R2PTGER1MAPT | |
| SCHEMBL8418430 | 0.77 | LTB4R (0.52) | LTB4RLTB4R2PKMKDM4EFFAR1 | |
| SCHEMBL4961192 | 0.77 | LTB4R (0.49) | LTB4RLTB4R2PKMKDM4EPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |