Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 15/20 | 0.42 |
| ▸ | CCND1 | P24385 | 15/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427437 | 0.85 | GPR84 (0.42) | HTR7CDK4CCND1CDK2GPR84 | |
| SCHEMBL8427079 | 0.78 | GPR84 (0.44) | CDK4CCND1CDK2GPR84 | |
| SCHEMBL5431339 | 0.75 | HTR7 (0.60) | HTR7GPR84SNCACYP1A2CYP2D6 | |
| SCHEMBL18767368 | 0.72 | KMT2A (0.49) | CDK4CCND1 | |
| SCHEMBL8422975 | 0.72 | SNCA (0.46) | HTR7SNCA | |
| SCHEMBL15143741 | 0.70 | CDK4 (0.44) | CDK4CCND1CDK2CYP1A2CYP2D6 | |
| SCHEMBL5424833 | 0.70 | HTR7 (0.72) | HTR7GPR84CYP1A2CYP2C9HSD17B10 | |
| SCHEMBL2879193 | 0.68 | MEN1 (0.71) | CDK4CCND1GPR84 | |
| SCHEMBL8425209 | 0.68 | NQO2 (0.55) | HTR7CDK2 | |
| SCHEMBL8785730 | 0.68 | HTR7 (0.68) | HTR7CYP1A2CYP2D6CYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-B1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5965745-A | ASTHMA; ANTIARTHRITIC,-SHOCK AGENTS; BRONCHITIS; RESPIRATORY SYSTEM DISEASES, E.G. CHRONIC OBSTRUCTIVE AIRWAYS DISEASES; PSORIASIS; ALLERGIC RHINITIS; ATOPIC DERMATITIS | PFIZER INC (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0863873-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997013751-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1997-04-17 | — | — | WO | disclosed |