Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 8/20 | 0.40 |
| ▸ | CCND1 | P24385 | 8/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427437 | 0.88 | GPR84 (0.42) | GPR84ROCK2ROCK1CDK4CCND1 | |
| SCHEMBL8425280 | 0.83 | GPR84 (0.56) | GPR84CYSLTR2CYSLTR1RXFP1IDO1 | |
| SCHEMBL8530246 | 0.83 | GPR84 (0.65) | GPR84CYSLTR2CYSLTR1RXFP1IDO1 | |
| SCHEMBL8427078 | 0.78 | GPR84 (0.46) | GPR84CYSLTR2CYSLTR1 | |
| SCHEMBL8422984 | 0.78 | HTR7 (0.42) | GPR84CDK4CCND1CDK2 | |
| SCHEMBL8528458 | 0.72 | GPR84 (0.73) | GPR84CYSLTR2CYSLTR1IDO1CPT1A | |
| SCHEMBL8427130 | 0.70 | GPR84 (0.67) | GPR84CYSLTR2CYSLTR1IDO1CDK2 | |
| SCHEMBL8425282 | 0.70 | GPR84 (0.58) | GPR84CYSLTR2CYSLTR1RXFP1IDO1 | |
| SCHEMBL29251314 | 0.68 | GPR84 (0.78) | GPR84RXFP1CDK2TDP1 | |
| SCHEMBL10765512 | 0.68 | GPR84 (0.55) | GPR84CYSLTR2CYSLTR1IDO1CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-B1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5965745-A | ASTHMA; ANTIARTHRITIC,-SHOCK AGENTS; BRONCHITIS; RESPIRATORY SYSTEM DISEASES, E.G. CHRONIC OBSTRUCTIVE AIRWAYS DISEASES; PSORIASIS; ALLERGIC RHINITIS; ATOPIC DERMATITIS | PFIZER INC (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0863873-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997013751-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1997-04-17 | — | — | WO | disclosed |