SCHEMBL8423375

SCHEMBL8423375

Cn1ncc(C(=O)c2ccc(Cl)c(N)c2Cl)c1O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.34
SRC P12931 4/20 0.34
FGFR2 P21802 4/20 0.34
FGFR4 P22455 4/20 0.34
FGFR3 P22607 4/20 0.34
KDR P35968 4/20 0.34
HTT P42858 2/20 0.33
BPTF Q12830 2/20 0.32
POLB P06746 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
LMNA P02545 1/20 0.31
MAOA P21397 1/20 0.30
ACHE P22303 1/20 0.30
MAOB P27338 1/20 0.30
CYP1A2 P05177 1/20 0.30
PKM P14618 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10729447 0.87 HTT (0.34) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL10724382 0.84 PKM (0.34) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL14570932 0.81 FGFR1 (0.31) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL22945925 0.81 CNR1 (0.33) HTTPOLBSMN1; SMN2LMNAALDH1A1
SCHEMBL4496557 0.79 SMN1; SMN2 (0.36) FGFR1KDRHTTBPTFPOLB
SCHEMBL9076331 0.79 KDM4E (0.38) CYP1A2PKMALDH1A1HPGDKMT2A
SCHEMBL27941481 0.78 SMN1; SMN2 (0.38) HTTSMN1; SMN2LMNAALDH1A1MAPT
SCHEMBL9078850 0.78 KMO (0.33) SMN1; SMN2LMNACYP1A2PKMALDH1A1
SCHEMBL10725158 0.77 SMN1; SMN2 (0.50) HTTPOLBSMN1; SMN2LMNACYP1A2
SCHEMBL4507444 0.77 PDE4D (0.39) SMN1; SMN2ALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11292849-A None JP disclosed
JP-H11292849-A BENZOYLPYRAZOLE COMPOUND AND HERBICIDE NIPPON SODA CO LTD 1999-10-26 JP disclosed