Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853047 | 0.82 | NPC1 (0.61) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2154879 | 0.82 | NPC1 (0.52) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Diphenylamine SCHEMBL3206649 | 0.79 | GAA (0.65) | LMNACYP2D6MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5593961 | 0.78 | MGLL (0.57) | HPGDCA12CA1CA2CA9 | |
| SCHEMBL5595197 | 0.77 | PTGS2 (0.54) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4854992 | 0.77 | PTGS2 (0.54) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13836876 | 0.77 | SMN1; SMN2 (0.73) | LMNACYP2D6MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL932442 | 0.77 | SMN1; SMN2 (0.73) | LMNACYP2D6MAPK1ALDH1A1SMN1; SMN2 | |
| Toluene SCHEMBL180606 | 0.77 | SMN1; SMN2 (0.65) | LMNACYP2D6MAPK1ALDH1A1SMN1; SMN2 | |
| Hno SCHEMBL3391939 | 0.77 | GAA (0.56) | LMNACYP2D6MAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5237045-A | Heat-resistant polytriazines using acid salts of aromatic amines as catalysts for aromatic tetracyano monomers; kinetics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1993-08-17 | — | — | US | claimed |
| US-20190284341-A1 | 3-OXO-2-ALKYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2019-09-19 | — | — | US | disclosed |
| US-20190284339-A1 | THERMOSET 3-OXO-ISOINDOLINE DIPHTHALONITRILE POLYMERS, METHOD OF MANUFACTURE, AND USES THEREOF | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2019-09-19 | — | — | US | disclosed |
| US-20190284340-A1 | 3-OXO-2-ARYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2019-09-19 | — | — | US | disclosed |
| EP-3539948-A1 | 3-OXO-2-ARYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | SABIC Global Technologies B.V. (NL) | 2019-09-18 | — | — | EP | disclosed |
| EP-3539950-A1 | 3-OXO-2-ALKYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | SABIC Global Technologies B.V. (NL) | 2019-09-18 | — | — | EP | disclosed |
| EP-3539949-A1 | THERMOSET 3-OXO-ISOINDOLINE DIPHTHALONITRILE POLYMERS, METHOD OF MANUFACTURE, AND USES THEREOF | SABIC Global Technologies B.V. (NL) | 2019-09-18 | — | — | EP | disclosed |
| US-5939508-A | High temperature epoxy-phthalonitrile blends | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1999-08-17 | — | — | US | disclosed |
| US-5389441-A | Phthalonitrile prepolymer as high temperature sizing material for composite fibers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1995-02-14 | — | — | US | disclosed |
| US-5237045-A | Heat-resistant polytriazines using acid salts of aromatic amines as catalysts for aromatic tetracyano monomers; kinetics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1993-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284341-A1 | 3-OXO-2-ALKYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | CYP1B1, CYP2J2, CYP1A1 | LMNA 3146/4885CYP2D6 30/4885MAPK1 1326/4885 |
| US-20190284340-A1 | 3-OXO-2-ARYLISOINDOLINE DIPHTHALONITRILE MONOMERS, METHODS OF MANUFACTURE, THERMOSETTING COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF | CYP1B1, CYP1A1, RECQL | LMNA 3067/4885CYP2D6 25/4885MAPK1 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.