Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | SNCA | P37840 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11773321 | 0.90 | SNCA (0.74) | GAAMEN1KMT2ASNCAHPGD | |
| SCHEMBL9479439 | 0.88 | SNCA (0.73) | GAAMEN1KMT2ASNCAHPGD | |
| SCHEMBL315795 | 0.88 | SNCA (0.73) | GAAMEN1KMT2ASNCAHPGD | |
| Toluene SCHEMBL180606 | 0.86 | SMN1; SMN2 (0.65) | GAASNCAHPGDCA1CA2 | |
| SCHEMBL932442 | 0.86 | SMN1; SMN2 (0.73) | GAASNCAHPGDCA1CA2 | |
| Diphenylamine SCHEMBL28417536 | 0.86 | TSHR (0.73) | GAAMEN1KMT2ASNCACA1 | |
| SCHEMBL13836876 | 0.86 | SMN1; SMN2 (0.73) | GAASNCAHPGDCA1CA2 | |
| Benzene SCHEMBL5085625 | 0.86 | SMN1; SMN2 (0.64) | GAASNCACA1CA2CA12 | |
| SCHEMBL27917348 | 0.84 | ALDH1A1 (0.58) | GAAMEN1KMT2ASNCAHPGD | |
| Water SCHEMBL14660542 | 0.84 | SMN1; SMN2 (0.70) | GAASNCAHPGDCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2067770-B1 | PROCESS FOR PRODUCTION OF SULFONIC ACID ESTER | WAKO PURE CHEM IND LTD (JP) | 2017-04-12 | — | — | EP | disclosed |
| US-8269038-B2 | Process for production of sulfonic acid ester | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2012-09-18 | — | — | US | disclosed |
| US-20100041916-A1 | PROCESS FOR PRODUCTION OF SULFONIC ACID ESTER | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2010-02-18 | — | — | US | disclosed |
| EP-2067770-A1 | PROCESS FOR PRODUCTION OF SULFONIC ACID ESTER | Wako Pure Chemical Industries, Ltd. (JP) | 2009-06-10 | — | — | EP | disclosed |
| EP-0736574-B1 | Thermoplastic resin composition comprising carbonate and acrylic resin | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| US-6103827-A | A TRANSPARENT THERMOPLASTIC RESIN BLENDS | GENERAL ELECTRIC COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| US-5883194-A | RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0736574-A2 | Thermoplastic resin composition comprising carbonate and acrylic resin | GENERAL ELECTRIC COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041916-A1 | PROCESS FOR PRODUCTION OF SULFONIC ACID ESTER | SULT1A1, SULT2A1, STS | GAA 1191/4885MEN1 3623/4885KMT2A 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.