Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8423845 | 1.00 | BBOX1 (0.43) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL3166085 | 0.92 | CA1 (0.43) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL19667848 | 0.88 | CA1 (0.41) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL21815723 | 0.88 | CA1 (0.45) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL6553020 | 0.88 | CA1 (0.45) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL6553031 | 0.88 | CA1 (0.45) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL31180066 | 0.85 | BBOX1 (0.43) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL31319750 | 0.85 | BBOX1 (0.43) | BBOX1CA1CA9CA4FAHD1 | |
| Fumaric Acid SCHEMBL23828619 | 0.84 | — | — | |
| Fumaric Acid SCHEMBL21815644 | 0.84 | CA1 (0.43) | BBOX1CA1CA9CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114106413-B | Preparation method of organic ester chelated metal type chlorine-containing plastic composite stabilizer | 北京理工大学鲁南研究院 | 2022-07-12 | — | — | CN | claimed |
| CN-110305440-B | Environment-friendly flame-retardant ABS (acrylonitrile-butadiene-styrene) composite material and preparation method thereof | 金发科技股份有限公司 | 2021-07-13 | — | — | CN | claimed |
| WO-2020253483-A1 | ENVIRONMENT-FRIENDLY FLAME-RETARDANT ABS COMPOSITE MATERIAL AND PREPARATION METHOD THEREFOR | 金发科技股份有限公司 | 2020-12-24 | — | — | WO | claimed |
| CN-110339787-A | A kind of gas-solid-liquid three-phase gel, preparation method and application | 中国科学院苏州纳米技术与纳米仿生研究所 | 2019-10-18 | — | — | CN | claimed |
| CN-110305440-A | A kind of environment-friendly flame-resistant ABS composite material and preparation method | 金发科技股份有限公司 | 2019-10-08 | — | — | CN | claimed |
| CN-109096504-A | A kind of gradient gel, preparation method and application | 中国科学院苏州纳米技术与纳米仿生研究所 | 2018-12-28 | — | — | CN | claimed |
| CN-108219184-A | Cyclodextrin aeroge, preparation method and application | 中国科学院苏州纳米技术与纳米仿生研究所 | 2018-06-29 | — | — | CN | claimed |
| CN-106279263-B | The preparation method of Methyltin maleate | 湖北犇星化工有限责任公司 | 2018-06-05 | — | — | CN | claimed |
| CN-103642178-B | A kind of Halogen-free flame-retardant thermoplastic polyester elastomer nano composite material and preparation method thereof | 合肥安聚达新材料科技有限公司 | 2017-03-15 | — | — | CN | claimed |
| CN-106279263-A | The preparation method of Methyltin maleate | 湖北犇星化工有限责任公司 | 2017-01-04 | — | — | CN | claimed |
| CN-102503972-B | Methyltin maleate and preparation method thereof | QUZHOU JIANHUA DONGXU AGENT CO LTD | 2015-06-17 | — | — | CN | claimed |
| CN-103642178-A | Halogen-free flame-retardant thermoplastic polyester elastomer nano composite material and preparation method thereof | HEFEI ANJUDA NEW MATERIAL TECHNOLOGY CO LTD | 2014-03-19 | — | — | CN | claimed |
| CN-120158035-A | PVC/ABS alloy material and preparation method and application thereof | 金发科技股份有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-119775683-A | High-whiteness PVC composition, and preparation method and application thereof | 金发科技股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-117924861-A | CPVC alloy material and application thereof | 金发科技股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-113881152-B | Transparent flame-retardant master batch as well as preparation method and application thereof | 江苏金发科技新材料有限公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-0761756-B1 | STABILIZER FOR HALOGEN-CONTAINING RESINS AND PROCESS FOR THE PREPARATION THEREOF, HALOGEN-CONTAINING RESIN COMPOSITION, AND COMPOSITE HYDROXIDE SALT | FUJI CHEM IND CO LTD (JP) | 1999-10-27 | — | — | EP | disclosed |
| EP-0947468-A1 | NOVEL COMPOSITE METAL HYDROXIDE SALTS, STABILIZER FOR HALOGENORESINS, AND HALOGENORESIN COMPOSITION | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| US-5840792-A | STABILIZER FOR HALOGEN-CONTAINING RESIN | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0761756-A1 | STABILIZER FOR HALOGEN-CONTAINING RESINS AND PROCESS FOR THE PREPARATION THEREOF, HALOGEN-CONTAINING RESIN COMPOSITION, AND COMPOSITE HYDROXIDE SALT | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |