Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 8/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635590 | 0.74 | P2RX4 (0.39) | P2RX4MTNR1AMTNR1BPTBP1P2RX1 | |
| SCHEMBL11741326 | 0.74 | P2RX4 (0.42) | P2RX4PTBP1P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL7334709 | 0.73 | LMNA (0.47) | P2RX4GRIN1GRIN2AGRIN2BPTBP1 | |
| SCHEMBL5803934 | 0.70 | P2RX4 (0.33) | P2RX4PTBP1P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL11276030 | 0.69 | MAOB (0.34) | — | |
| SCHEMBL11282186 | 0.68 | P2RX4 (0.33) | P2RX4PTBP1P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL8423850 | 0.67 | P2RX4 (0.37) | P2RX4MTNR1AMTNR1BNAMPTKDM5B | |
| SCHEMBL30592971 | 0.67 | CYP3A4 (0.40) | P2RX4PTBP1P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL5804812 | 0.65 | SMN1; SMN2 (0.48) | RIPK1SMN1; SMN2 | |
| SCHEMBL16363803 | 0.64 | GRIN1 (0.54) | MTNR1AMTNR1BNAMPTGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962450-A | SEDATIVE | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5885986-A | CLEAVING, N-ALKYLATING AND REDUCING THE INTERMEDIATE FORMED BY REACTING AN OXAZOLYL AND THIAZOLYLIMIDAZOBENZO AND THIENODIAZEPINE DERIVATIVES WITH AMINE COMPOUNDS; USED AS ANXIOLYTIC AND ANTICONVULSANT OR SEDATIVE-HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-23 | — | — | US | disclosed |