Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422143 | 1.00 | PTGS2 (0.48) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8423982 | 0.94 | PTGS2 (0.46) | PTGS2CA1CA2CA9CYP2C9 | |
| SCHEMBL8423066 | 0.92 | MEN1 (0.45) | PTGS2PTGS1CYP2C9KDM4EMEN1 | |
| SCHEMBL8421778 | 0.91 | PTGS2 (0.56) | PTGS2PTGS1CYP2C9KDM4EMEN1 | |
| SCHEMBL8423857 | 0.91 | MEN1 (0.44) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8733829 | 0.89 | PTGS2 (0.54) | PTGS2PTGS1CYP2C9KDM4EMEN1 | |
| SCHEMBL8423816 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1MAPK9PDPK1 | |
| SCHEMBL8422286 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1CYP2C9KDM4EMEN1 | |
| SCHEMBL8423767 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1CYP2C9KDM4EMEN1 | |
| SCHEMBL8423819 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1CA1CA2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |