Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259264 | 0.76 | ATM (0.48) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL4559941 | 0.76 | ATM (0.48) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL4620642 | 0.76 | ATM (0.48) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL3535166 | 0.76 | ATM (0.48) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL9769252 | 0.73 | ATM (0.45) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL5250885 | 0.73 | ATM (0.45) | ATMNPC1RAB9AKDM4EGPR3 | |
| SCHEMBL9769436 | 0.72 | ATM (0.44) | ATMNPC1RAB9A | |
| SCHEMBL8423013 | 0.72 | ATM (0.44) | ATMNPC1RAB9ACYP1A2CYP2A6 | |
| SCHEMBL6081734 | 0.72 | ATM (0.44) | ATMNPC1RAB9A | |
| SCHEMBL4288878 | 0.72 | ATM (0.44) | ATMNPC1RAB9APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117802586-A | Synthesis method of On-DNA 2-thioquinazolinone compound | 重庆大学 | 2024-04-02 | — | — | CN | claimed |
| CN-113354592-B | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2022-06-21 | — | — | CN | claimed |
| CN-113354592-A | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2021-09-07 | — | — | CN | claimed |
| JP-7110541-A | — | — | None | — | — | JP | disclosed |
| CN-117802586-A | Synthesis method of On-DNA 2-thioquinazolinone compound | 重庆大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-117802586-A | Synthesis method of On-DNA 2-thioquinazolinone compound | 重庆大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-117802586-A | Synthesis method of On-DNA 2-thioquinazolinone compound | 重庆大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-113354592-B | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113354592-B | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113354592-B | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113354592-A | 2-thioquinazolinone compound and preparation method and application thereof | 赣南师范大学 | 2021-09-07 | — | — | CN | disclosed |
| US-5175164-A | Hypotensive agents | MERCK & CO., INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0517357-A1 | Angiotensin II antagonists incorporating a substituted indole or dihydroindole | MERCK & CO. INC. (US) | 1992-12-09 | — | — | EP | disclosed |
| EP-0515535-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0512870-A1 | Substituted quinazolinones bearing acidic functional groups as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0512676-A1 | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-5162325-A | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0510812-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991012001-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0411766-A1 | Substituted quinazolinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-02-06 | — | — | EP | disclosed |