Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17072223 | 0.78 | CYP1A2 (0.42) | ATMCYP1A2CYP2A6KDM4EGPR3 | |
| SCHEMBL8424490 | 0.76 | ATM (0.48) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL5259264 | 0.76 | ATM (0.48) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL4620642 | 0.76 | ATM (0.48) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL4559941 | 0.76 | ATM (0.48) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL8423013 | 0.76 | ATM (0.44) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL3540325 | 0.74 | NOS1 (0.33) | ATMCYP1A2CYP2A6RAB9AHTT | |
| SCHEMBL5250885 | 0.73 | ATM (0.45) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL9769252 | 0.73 | ATM (0.45) | ATMCYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL6081734 | 0.72 | ATM (0.44) | ATMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680272-B2 | 3-arylethynyl substituted quinazolinone compounds | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-03-25 | — | — | US | disclosed |
| US-20130317221-A1 | 3-ARYLETHYNYL SUBSTITUTED QUINAZOLINONE COMPOUNDS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-11-28 | — | — | US | disclosed |
| WO-2012111017-A1 | 3-ARYLETHYNYL SUBSTITUTED QUINAZOLINONE COMPOUNDS | CONCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-23 | — | — | WO | disclosed |
| US-7829566-B2 | Such as (7-chloro-2-styryl-quinazolin-4-yl)-(3-imidazol-1-yl-propyl)-amine; glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | MEDERSKI WERNER | 2010-11-09 | — | — | US | disclosed |
| US-20070293667-A1 | 4-Amino-quinazolines | MEDERSKI WERNER | 2007-12-20 | — | — | US | disclosed |
| WO-2004030671-A2 | USE OF 4-AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| US-20040044204-A1 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| CN-1474816-A | 4-amino-quinazolines | Ĭ��ר���ɷ�����˾ | 2004-02-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044204-A1 | 4-amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | ATM 4247/4885CYP1A2 1069/4885CYP2A6 2973/4885 |
| US-20130317221-A1 | 3-ARYLETHYNYL SUBSTITUTED QUINAZOLINONE COMPOUNDS | NQO2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NQO1 | ATM 1754/4885CYP1A2 90/4885CYP2A6 283/4885 |
| US-20070293667-A1 | 4-Amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | ATM 3669/4885CYP1A2 1179/4885CYP2A6 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.