⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5518230 | 0.83 | — | — | |
| SCHEMBL13134161 | 0.81 | JAK3 (0.42) | — | |
| SCHEMBL9954231 | 0.79 | HRH2 (0.43) | — | |
| SCHEMBL14253913 | 0.79 | HRH2 (0.42) | — | |
| SCHEMBL8425012 | 0.76 | HRH2 (0.45) | — | |
| SCHEMBL13134163 | 0.75 | TGM2 (0.40) | — | |
| SCHEMBL9109986 | 0.74 | CYP17A1 (0.41) | — | |
| SCHEMBL18372644 | 0.71 | HRH2 (0.41) | — | |
| SCHEMBL4412558 | 0.70 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL84832 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222875-A1 | BENZOPYRIMIDINE TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPPLICATION THEREOF | 昆药集团股份有限公司 | 2022-10-27 | — | — | WO | disclosed |
| US-9943603-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2018-04-17 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |
| US-5874501-A | POLY(P-HYDROXYSTYRENE) WITH AROMATIC MOIETY AND ALIPHATIC MOIETY WITH INORGANIC OXIDE | KEEHAN DONALD J (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0407554-B1 | METALLIC OXIDE-OXIRANE POLYMERS AND PREPOLYMERS | KEEHAN DONALD J (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1997031047-A1 | MULTI-FUNCTIONAL OXIRANE POLYMERS | KEEHAN DONALD J (US) | 1997-08-28 | — | — | WO | disclosed |
| US-5658996-A | A LIQUID POLYEPOXIDE PREPOLYMER THE REACTION PRODUCT OF A TRISHYDROXYPHENYL, AN AROMATIC DIGLYCIDYL ETHER AND METAL OXIDE; CURABLE, LOW VISCOSITY; FORMED POLYEPOXIDE IS HEAT AND CHEMICAL RESISTANCE, ELONGATION, TOUGHNESS | KEEHAN DONALD J (US) | 1997-08-19 | — | — | US | disclosed |
| US-5169912-A | Hydrolyzable oxygen bonding with epoxide; silica, titania; high performance coatings, adhesives | KEEHAN DONALD J (US) | 1992-12-08 | — | — | US | disclosed |
| US-5026816-A | Reaction product of diglycidyl ether of (bisphenol a or resorcinol) with metallic oxide in presence of imidazole catalyst | KEEHAN DONALD J (US) | 1991-06-25 | — | — | US | disclosed |
| WO-1990008168-A1 | METALLIC OXIDE-OXIRANE POLYMERS AND PREPOLYMERS | KEEHAN DONALD J (US) | 1990-07-26 | — | — | WO | disclosed |
| US-4880892-A | PHOSPHONIUM OR PHOSPHORANE CATALYST, PROTECTIVE COATINGS | CIBA-GEIGY CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |